Post: #1

The topic of leaky gut syndrome has been touched upon in many threads but due to the global rise in cases, I think it merits its own thread where we can centralize ideas.

I'm pretty sure I have it.

I've been having digestion issues for about 2 years. Back then I became lactose intolerant seemingly overnight, and since then I have noticed sudden mild intolerances to certain foods, like oats.

This issue manifests itself in the form of alternating constipation and diarrhea; gas/bloating; chronic fatigue and mental fogginess. I also have a terrible case of seborrheic dermatitis which seems to be closely related to my diet rather than being a topical, skin problem.

As suddenly as they come, these intolerances also cease. For the past few months I've been able to consume dairy again and my SD virtually disappeared.

Two weeks ago it started flaring up again and my scalp/eyebrows are terrible, as well as gas/bloating issues.

I've been mostly vegetarian for the past 12 months, eating meat sporadically, but from what I've read bone broth seems like a great tool to heal the digestive tract - which I'm willing to try. I reckon some type of vitamin supplementation could also help but it's probably best to do a blood panel before fiddling with it.

Any other ideas?

Post: #2

Your digestive tract is a tube which absorbs food. It has a bunch of micro fingers sticking out to absorb food. On those little fingers live bacteria which pre-digest the food so you can easily absorb it through the gut and into blood. In short from inflammation and damage to the "skin" - since that's all it really is, you gut is allowing larger foreign particles through. This is why you started seeing lots of symptoms at once. Just visualize food in your gut and a combination of a bad diet damaging the "skin" and bacteria that should be digesting the food gone due to modern food processing, which amplifies the problem.
Here is what I would suggest, give it time to heal. You are right to not eat meat or anything heavy to digest for a few weeks . Go to a Korean store and buy a gallon of kimchi or any other sort of fermented food (there is an entire thread on this forum for that). Try some kombucha and make it yourself if you like it. These will reintroduce productive bacteria. Bone broth is good as well, lots of micro nutrients and the gelatine will patch up your gut in a way.
Check out underground wellness on YouTube. Kbell from this forum sent me a write up once from one of their lectures. It's a bit better because its final (on YouTube you sort of follow his self discovery rather than grand picture overview) . Don't have it anymore but if you ask him and he does I'm sure he'll share it.

Post: #3

Sauerkraut solved an issue similar to this for me a couple of years back. Amazing for your stomach.

Post: #4

See a GI doctor and you most likely will get a colonosopy and the barium test. Rule out that you don't have Chrohns, Colitis or gut disease. Diet doesn't remove all gut disorders. Strict diets like specific carb diet, paleo whole30, and GAPS might be of help too.

Post: #5

A Primal Primer: Leaky Gut

Quote:How do you know if you have leaky gut?

Everyone’s gut is a little leaky, a little permissive if not downright permeable.

One way is to take an intestinal permeability test. You drink a solution containing a pre-measured amount of mannitol and lactulose, two indigestible sugars. You collect your urine over the next 6 hours and measure the amount of excreted mannitol and lactulose to determine how much permeated through your gut.

Another way is to measure levels of blood zonulin, a reliable marker of intestinal permeability. You might have trouble convincing your doctor to order this one.

You can also look at the list of conditions commonly associated with elevated intestinal permeability. If you have any or all of them, you may have leaky gut. Put another way, if you have leaky gut, you may be at a greater risk for some of these. What are they?

Celiac disease: When gluten is broken up into fragments in the gut, those fragments induce the release of zonulin, which tells the tight junctions to become more permeable. This happens to everyone whose guts come into contact with those gluten fragments, but the effect is enhanced in people with celiac. Their gluten-induced leaky gut is way more leaky than it should be, and it stays leaky long after the gluten has been gone. In fact, before direct testing for gluten antibodies and intestinal damage became widespread, a common test for celiac used to be the very same intestinal permeability assessment I just mentioned.

Inflammatory bowel disease (IBD): Patients with Crohn’s disease, an inflammatory bowel disease characterized by severe inflammation of the gut lining, tend to have leaky gut. And in general IBD, which includes Crohn’s and ulcerative colitis, high intestinal permeability precedes the development of the disease.

Irritable bowel syndrome (IBS): As discussed yesterday, IBS patients often show increased gut permeability. Some researchers suggest that leaky gut leads to the kind of chronic, low-level inflammation that characterizes IBS.

Asthma: There is a high prevalence of leaky gut in people with moderate to severe asthma, though researchers aren’t sure whether it’s a cause or consequence of the asthma.

Food allergies and intolerances: The transportation of the food allergen across the gut lining appears to be a necessary step in the development of a food allergy, and a 2011 review concluded that an overly leaky gut facilitates this transportation and leads to the inducement of allergy.

Autism: Children with autism and their first-degree relatives tend to have abnormal gut permeability, suggesting a gene-environment component to autism. This is present in some, but not all people with autism.

Rheumatoid arthritis, ankylosing spondylitis, and other autoimmune diseases: Both RA and AS have been linked to leaky gut, and the connection may hold for other autoimmune diseases, too.

Obesity and metabolic syndrome: Both obesity and metabolic syndrome are often linked with intestinal permeability, and a recent paper explores all the potential mechanisms that might explain the link.

Depression: By some accounts, 35% of depressed patients have leaky gut.

Eczema: Going back as far as 1986, researchers have found leaky gut to be common in eczema patients.

Interesting, huh? Leaky gut really gets around. It may not be the whole story, and some of these connections may be coincidental, but plausible mechanisms exist for most of them and I’m confident that fixing leaky gut will improve many seemingly disparate health problems.

Plus, even if it wasn’t the proximate cause of your health problems, leaky gut probably isn’t helping you get better and you should try to fix it. Multiple feedback loops which make teasing apart cause and effect nearly impossible also make it possible to step in the middle of the loop(s) and break it up.

Quote:What should you do?

First, avoid things that might cause it.

Gluten. Gluten begets gliadin releases zonulin induces leaky gut. I discussed this in the celiac section above, but it’s important to reiterate that gliadin has this leaky effect on every gut, not just in celiacs. Celiacs just get it worse than non-celiacs.

Stress. Stress can directly induce leaky gut (PDF) and stress can take many forms, as we all know. Bad finances, marital strife, unemployment, too much exercise, lack of sleep, extended combat training, and chronic under-eating all qualify as significant stressors with the potential to cause leaky gut, especially chronically and in concert.

Too much alcohol. Ethanol increases intestinal permeability by changing the gene expression of the proteins involved in tight junction function. If you do drink, be sure to follow best practices and definitely do not drink on an empty stomach. Alcohol also depletes zinc, which is a crucial pro-gut nutrient.

Poor sleep habits. In one recent study, mice whose circadian rhythms were disrupted were more susceptible to liver damage and alcohol-induced intestinal permeability.

NSAIDs. Non-steroidal anti-inflammatory drugs like aspirin and ibuprofen can be helpful in certain situations, but they are far from benign. One of their worst and most pronounced effects is leaky gut.

Then, take proactive steps to improve gut barrier function.

Take whey protein isolate and glutamine. Both supplements have been shown to reduce leaky gut in patients with Crohn’s disease.

Try resistant starch and other prebiotics. Whether potato starch, green bananas/plantains, mung bean starch, inulin powder, jersualem artichokes, leeks, pectin, or apples, start eating RS and other prebiotics on a regular basis. They increase butyrate production (which reduces intestinal permeability) and support the growth and maintenance of healthy microbial populations.

Take probiotics and/or (preferably “and”) eat fermented food. Prebiotics are important, but you also need to provide the right gut bugs if you’re deficient. You can do it with both supplements and food. L. rhamnosus and L. reuteri supplements reduce leaky gut and improve symptoms in kids with atopic dermatitis. L. rhamnosus also helps restore the gut barrier in kids with acute gastroenteritis. In rats with leaky gut, yogurt improves gut barrier function.

Get adequate sunlight and/or take vitamin D3 supplements. Vitamin D helps protect against injuries to the intestinal lining, while a vitamin D deficiency promotes intestinal permeability and inflammation.

Get enough zinc. Oysters, red meat, supplements – zinc supplementation reduces leaky gut.

Make broth, eat gelatinous cuts of meat. I don’t have any scientific references for this one, but it’s such a staple piece of advice in the “healing your gut” scene that it’s worth including. Plus, oxtails are magic, and science can’t quite explain magic just yet.

Exercise intelligently. Intense, protracted exercise induces leaky gut. This is normally transient and totally manageable, but if taken to the extreme as in chronic cardio, exercise-induced leaky gut can become a chronic condition. The same goes for any kind of chronic exercise. Even too much strength training can probably do it, though you’d have to do a ton of volume without much rest. Meanwhile, moderate exercise improves gut barrier function. The tried and true triumvirate of lifting heavy things, walking lots, and sprinting occasionally is the safest bet.

Post: #6

I prefer the KISS philosphy when it comes to health issues especially GI stuff.

How's your fiber intake? Seriously, i was having all sorts of dietary issues and then started supplementing psyllium in. This proved to be a god send and helped my gut problems.

That and fermented foods will help too. Sauerkruat and the korean thing mentioned above.

Post: #7

I'm currently listening to this guy John Rose who has a lot of interesting points. I am looking for the right opportunity to start a juice fast.

Post: #8

(09-17-2016 07:01 AM)The Beast1 Wrote:  I prefer the KISS philosphy when it comes to health issues especially GI stuff.

How's your fiber intake? Seriously, i was having all sorts of dietary issues and then started supplementing psyllium in. This proved to be a god send and helped my gut problems.

That and fermented foods will help too. Sauerkruat and the korean thing mentioned above.

I actually take significant psyllium, but do to lack of ease of carrying it, only once a day, a whole scoop full. I've noticed that when I eat fried chicken or other foods like pizza, maybe some fast foods or even hot (spicy) foods like mexican, psyllium is the only chance I have at keeping it together. Weird. Just started like 3 years ago, I'm mid 30s

Post: #9

I must say that I'm 100% positive also that candida or other yeast overgrowth has been proven in my case, if interested PM me I'll tell you. It is a component, and possibly the largest one, but what's weird is that when it comes to diet I am disciplined as to what goes in: I intermittent fast, eat good foods a lot, but I guess I also eat pizza, some fast foods, and drink alcohol occasionally. Stuff I'm sorta not willing to part with because the symptoms (physical consistency of bowel movements) are more weird than painful or "bad."

Post: #10

(09-16-2016 10:45 AM)Ringo Wrote:  This issue manifests itself in the form of alternating constipation and diarrhea; gas/bloating; chronic fatigue and mental fogginess. I also have a terrible case of seborrheic dermatitis which seems to be closely related to my diet rather than being a topical, skin problem.

That's interesting! For years now (since some time in my late 20s) I got this scalp problem - if I shampoo everyday, not a problem, but go without hair washing a day or two, crusty flaky "dandruff" forms. It's sometimes visible around my hairline on a bad day. I never knew it was Seborrheic Dermatitis.

I just googled that and it describes it perfectly, along with other new symptoms I've got in last few years, including behind the ears, eyebrows:

"You might get seborrheic dermatitis on your face, especially around your nose, on your eyelids, or behind your ears"

They (WebMD) say it's not related to allergies?

Without knowing for sure, my guess is that it's the damn chemicals being sprayed all over these fucking crops we all ingest - over-processing, fucking with plant genetics etc.

aka - Monsanto are to blame!

Post: #11

Kefir.

https://www.amazon.com/1TBSP-Active-Orga...r=8-1&th=1

Note: i am not associated with them.

I have GERD. At night i would wake up feeling like i am drowning and its basically acid that has nowhere to go but up my esophagus. I read about Kefir and bought the store brand (not real kefir) and decided to make my own. No more GERD.

It has a lot more good bacteria than yogurt and is a probiotic. It came out of the Caucasus mountains and in Turkish means "feel right".

I bought the above active grains and after a week had real kefir. You need to occasionally open the jar it is in because CO2 is emitted (that means its real kefir).

Some people cannot handle kefir at first so if you try it try a small amount. The wife flavors it with a bit of coffee creamer and it lasts.

To add: I swear by this. We overmedicate which kills good bacteria and causes a lot of gut issues. Kefir adds them back into your system.

Post: #12

My diet has always been very clean - no fast food, sodas, excessive sugar.

Fiber intake is good too (50g/day+). I was eating a lot of beans and lentils. Despite their fiber content and my efforts in preparing them to be more easily digested, I'm sure they didn't help with the bloating. This week is all rice, potatoes, broccoli, carrots, chicken and fruit (plus IF to give the digestive tract a break).

The heart of the issue (specially with the dandruff) seems to be some type of digestive problem associated with candida/yeast overgrow. Thanks KidTwist.

@Kbell:
You're right. I've researched this a fair deal and have an appointment with a GI on Thursday. This time I'm not taking any risks, I'm going to bring him all of the stuff I found and ask him about specific hypothesis.

@Sandstrom
Take a look at this: Seborrheic dermatitis - The owner's manual. It's a lot to read (it covers many concepts of human fisiology) but I think you may be interested.

Post: #13

For me there is no alternating. Ever since it started happening, it's been always loose, that's why psyllium is a must at this point. I cut out dairy for 1 month and it got slightly better; maybe it just needed even longer. I'm not sure what to do because I'm not in pain, but I could use a bide ha

Post: #14

What are your feelings on coffee/caffeine?

I have to say that within 2-3 years of drinking it regularly, though it was also associated with a professional program and probably stress as well, I finally experienced a change in stools. Then I realized a big component of it was candida or yeast, but maybe the coffee led to that? Any opinions are appreciated.

Post: #15

Are you sure this is not a form of Candida?

I would say cut all refined sugars out for a while. Even if it is not the primary cause, it will certainly be a net benefit. Lay off the booze, bread, simple carbs, dairy products. Eat loads of green veg, fish, eggs, avocados and lemons (although citric these turn to alkaline in the gut). Take a good probiotic with meals if you aren't already.

All of these habits will be beneficial to digestive health, whatever the specific cause IMHO.

Post: #16

I know I will probably get flamed for this, but leaky gut syndrome (while not disproven), is also not a proven diagnosis. There is really no solid medical literature that proves it exists (someone feel free to correct me). If anyone is having abdominal bloating as a main symptom and has had a negative workup, one possible solution if the FODMAPs diet. Basically foods that tend to have lower gas formation by gut bacteria. Stanford has a good list of foods which are high and low in these compounds.

For what it is worth, I do not personally have this issue.

Post: #17

I had been suffering from this for years. Finally found out that I was an undiagnosed Celiac, my symptoms have almost gone disappeared since I addressed that issue.

What I did find alleviated my symptoms of leaky gut during the worst of it was my sleeping position, I would wake in the morning and it felt like I had swallowed hot lava and by using a couple of pillows so my head was raised above my gut level prevented the worst of it whilst sleeping.

Also taking regular cider apple vinegar helped a lot, sounds like the worst thing to take in these circumstances bt it worked for me!

Jon

Post: #18

(09-19-2016 09:06 PM)DRE Wrote:  I know I will probably get flamed for this, but leaky gut syndrome (while not disproven), is also not a proven diagnosis. There is really no solid medical literature that proves it exists (someone feel free to correct me). If anyone is having abdominal bloating as a main symptom and has had a negative workup, one possible solution if the FODMAPs diet. Basically foods that tend to have lower gas formation by gut bacteria. Stanford has a good list of foods which are high and low in these compounds.

Just like the "Subluxations" of the Chiropractor, "leaky gut" is the unseen, unproven diagnoses of all manner of New Age specialists.

Post: #19

(09-20-2016 04:04 AM)JonboyUK Wrote:  I had been suffering from this for years. Finally found out that I was an undiagnosed Celiac, my symptoms have almost gone disappeared since I addressed that issue.

What I did find alleviated my symptoms of leaky gut during the worst of it was my sleeping position, I would wake in the morning and it felt like I had swallowed hot lava and by using a couple of pillows so my head was raised above my gut level prevented the worst of it whilst sleeping.

Also taking regular cider apple vinegar helped a lot, sounds like the worst thing to take in these circumstances bt it worked for me!

Jon

This is reflux...

Post: #20

(09-20-2016 12:10 PM)Baphomet Wrote:  

(09-19-2016 09:06 PM)DRE Wrote:  I know I will probably get flamed for this, but leaky gut syndrome (while not disproven), is also not a proven diagnosis. There is really no solid medical literature that proves it exists (someone feel free to correct me). If anyone is having abdominal bloating as a main symptom and has had a negative workup, one possible solution if the FODMAPs diet. Basically foods that tend to have lower gas formation by gut bacteria. Stanford has a good list of foods which are high and low in these compounds.

Just like the "Subluxations" of the Chiropractor, "leaky gut" is the unseen, unproven diagnoses of all manner of New Age specialists.

Agreed. I just feel that as a community of men who claim to be rational and grounded in reason we should base our medical conversations for the most part on actual scientific research, especially when it comes to sketchy diagnoses.

Post: #21

Welcome to the forum DRE.

Here are a couple of my early posts on here from the ACV thread. Bro Science man, where you been?

/thread-7518-page-25.html

I would highly recommend you read the books on the bottom post.

-------


Putting these posts here as I feel they are relevant to this issue.

I also agree with the Kid on the candida culprit, coffee and stress were also precursors to my episode, think stress came first followed by the coffee. The good (or if possible, organic) diet is a must during the acv/bicarb regime.

(01-08-2015 02:22 PM)Renton1875 Wrote:  Just spent ages writing a post & got mugged! Wiil now reduce & condense.

Roosh V Forum
Can not upload file - Too large for php post_max_size directive. Please press the back button.

Basically "Teds-ACV Alkalising Remedies" consists of mixing ACV(with the mother) & bicarbonate soda(UK)/baking soda(US).
Two tsp(small spoon/5ml) ACV, Half tsp(5ml) bicarbonate/baking soda, add these to 200 ml of fresh bottled water in a glass.
:IMPORTANT:-Then sip the mixture slowly (use straw if reqd) taking maybe two mins to consume.Don't gulp!
Do this twice a day morning/night for 5 days then have 2days off. Rinse & repeat.
Try to drink 2Ltrs of fresh bottled water daily which is needed to wash out all the toxins.
Possible downside for some is during this regime you should refrain from sugars, yeast & most processed foods to get the best results.
Yeh, I know,no beer, burgers, micro-meals, fruit juices, candy, soda etc. Try it for a cpl weeks, it's New Year!!
During first week you may develop man flu symptoms/other symptoms/flare ups etc, believe it or not these are good signs called Hrexheimer Effect which is toxin die-off.YEH!!Depending how much shit your bunged up with determines how bad & how long. Refrain from the above & you should see difference in first week or deffo 2nd
Where did I get Ted from Bangkok ACV Remedies from, well ROOSH tried to point y'all in the right direction on the first page of this thread.

(10-24-2011 12:59 AM) Roosh [226]
ACV got rid of some eczema that I had. More info: http://www.earthclinic.com/Remedies/acvinegar.html
Search site for Ted's ACV Remedies, he also explains chemistry/science behind it. ^^^^^^^ The whole site is one of best on the net for Alt Meds/Bro-Science

(01-08-2015 09:21 PM)Renton1875 Wrote:  Don't believe it, was mugged again for another long post. This one was explaining what the ACV & bicarbs helped me with about 6/7 years ago. Was suffering from burning the candle at both ends, immune system shot to death. Anyhowz, symptoms included:- chronic fatigue, sinusitis, athletes foot, white tongue, premature ejac(why am I sharing this!) & oh yeh, worst of all severe Hemorrhoids . Happy days!! Finally decided to visit doc's although could count on one hand how many times been at doc's during adult life. After watching doc google symptoms(I could've done that!) left surgery with handfuls of prescriptions for pill's, creames & suppositries, decided to investigate these meds on net & came across many horror stories! Many, many hours searching the net later I came across a new word for my vocabulary CANDIDA....... A particularly nasty little piece of shit that can cause havoc in any persons body, basically.its a form of (BAD)yeast overgrowth(thrush,as it's known in women & kids) docs seem to accept thrush can appear in the mouth and genital areas of women but can't get their heads around the space between these orifices. Mention candida to your doc & you'll be chased out of their surgery
Cut to the chase, after discovering a few good books, the earthclinic site & teds remedies it wasn't long before I was on the ACV/bicarbonate soda regime, strictly refraining from sugars, yeasts, bread(sourdough ok), etc. felt like shit for first two days then relief..... Had energy hadn't experienced since my teens, sinuses cleared(didn't realise sinuses were all over face,head & ears), athletes foot dried up to flaky skin, white tongue became pink(can't remember last time it was pink), sex became controllable again(could take her eye out with a ribbon from 3foot), best of all rhoids shrunk & disappeared. All this within first 5 days. HAIL ACV & BICARBS!!

(01-08-2015 10:33 PM)Renton1875 Wrote:  Finally!!!

Apart from the Ted Remedies & the rest of that website, the three books I'd recommend for RVFers on this subject are:-

Folk Medicine by Dr D C Jarvis.........Should be called "The ACV Handbook" written in the 1950's in Vermont,pre anti-biotics etc,he also gives it to animals/livestock etc

The Yeast Connection--A Medical Breakthrough by William G Crook MD.........Read this then go have a chat with your doctor, they'll be more educated after you leave!!

The Missing Diagnosis by C Orian Truss MD.......unbelievably true stories/cases of mis-diagnosis & the troubles it causes,should be first book given out at Med School!

Hope I haven't went off topic too much, who knows maybe some of you stressed out, candle burning,graveyard shift working RVFers will recognise some of the symptoms(maybe all of them!!) If so, give it a shot, what you got to lose?

P.S Also off topic but could someone PM me with a link to learn how to use the quote functions.

Thanks for your contribution to the discussion DRE and seriously, I sincerely hope you never do suffer from any digestive tract issues as Im sure you'd find the same doctors guys here have found, happy to prescribe potions and lotions to mask/alleviate the symptoms, but not interested in finding the cause. Even with all that scientific research behind them............

Post: #22

(09-20-2016 07:05 PM)DRE Wrote:  Just like the "Subluxations" of the Chiropractor, "leaky gut" is the unseen, unproven diagnoses of all manner of New Age specialists.

Agreed. I just feel that as a community of men who claim to be rational and grounded in reason we should base our medical conversations for the most part on actual scientific research, especially when it comes to sketchy diagnoses.
[/quote]

I undestand your skepticism but don't write it off as a real thing just yet.

"Leaky gut" can be an umbrella term that covers many different issues and it can be abused.

But that doesn't necessarily mean it isn't real. Posttraumatic stress disorder was also not considered a serious ailment either and received different names during the 20th century (shellshock, battle fatigue, neurosis, etc). Soldiers who suffered from it were often considered weaker men who couldn't keep it together.





In any case the topic of leaky gut is gaining more space in the scientific community. Research PubMed and you'll see 150+ mentions in articles and studies.

Quote:Leaky gut and autoimmune diseases.
Fasano

Abstract
Autoimmune diseases are characterized by tissue damage and loss of function due to an immune response that is directed against specific organs. This review is focused on the role of impaired intestinal barrier function on autoimmune pathogenesis. Together with the gut-associated lymphoid tissue and the neuroendocrine network, the intestinal epithelial barrier, with its intercellular tight junctions, controls the equilibrium between tolerance and immunity to non-self antigens. Zonulin is the only physiologic modulator of intercellular tight junctions described so far that is involved in trafficking of macromolecules and, therefore, in tolerance/immune response balance. When the zonulin pathway is deregulated in genetically susceptible individuals, autoimmune disorders can occur. This new paradigm subverts traditional theories underlying the development of these diseases and suggests that these processes can be arrested if the interplay between genes and environmental triggers is prevented by re-establishing the zonulin-dependent intestinal barrier function. Both animal models and recent clinical evidence support this new paradigm and provide the rationale for innovative approaches to prevent and treat autoimmune diseases.

http://www.ncbi.nlm.nih.gov/pubmed/22109896

Quote:Autoimmunity and the Gut
Andrew W. Campbell*

Abstract
Autoimmune diseases have increased dramatically worldwide since World War II. This is coincidental with the increased production and use of chemicals both in industrial countries and agriculture, as well as the ease of travel from region to region and continent to continent, making the transfer of a pathogen or pathogens from one part of the world to another much easier than ever before. In this review, triggers of autoimmunity are examined, principally environmental. The number of possible environmental triggers is vast and includes chemicals, bacteria, viruses, and molds. Examples of these triggers are given and include the mechanism of action and method by which they bring about autoimmunity.
[...]
In adults, chronic stress affects the composition of the gut microbiota with increase of Bacteroides spp. and Clostridium spp. Coupled with this are increasing levels of IL-6 indicating immune activation [105]. Chronic stress also makes the gut leaky, increasing circulating levels of LPS. Findings of altered intestinal permeability (leaky gut) may play a pathogenic role in patients with depression and their first-degree relatives [106, 107].

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4036413/

Quote:The gut-brain barrier in major depression: intestinal mucosal dysfunction with an increased translocation of LPS from gram negative enterobacteria (leaky gut) plays a role in the inflammatory pathophysiology of depression.
Maes M1, Kubera M, Leunis JC.

Abstract
There is now evidence that major depression (MDD) is accompanied by an activation of the inflammatory response system (IRS) and that pro-inflammatory cytokines and lipopolysacharide (LPS) may induce depressive symptoms. The aim of the present study was to examine whether an increased gastrointestinal permeability with an increased translocation of LPS from gram negative bacteria may play a role in the pathophysiology of MDD. Toward this end, the present study examines the serum concentrations of IgM and IgA against LPS of the gram-negative enterobacteria, Hafnia Alvei, Pseudomonas Aeruginosa, Morganella Morganii, Pseudomonas Putida, Citrobacter Koseri, and Klebsielle Pneumoniae in MDD patients and normal controls. We found that the prevalences and median values for serum IgM and IgA against LPS of enterobacteria are significantly greater in patients with MDD than in normal volunteers. These differences are significant to the extent that a significant diagnostic performance is obtained, i.e. the area under the ROC curve is 90.1%. The symptom profiles of increased IgM and IgA levels are fatigue, autonomic and gastro-intestinal symptoms and a subjective feeling of infection. The results show that intestinal mucosal dysfunction characterized by an increased translocation of gram-negative bacteria (leaky gut) plays a role in the inflammatory pathophysiology of depression. It is suggested that the increased LPS translocation may mount an immune response and thus IRS activation in some patients with MDD and may induce specific "sickness behaviour" symptoms. It is suggested that patients with MDD should be checked for leaky gut by means of the IgM and IgA panel used in the present study and accordingly should be treated for leaky gut.

http://www.ncbi.nlm.nih.gov/pubmed/18283240

Post: #23

(09-20-2016 12:10 PM)Baphomet Wrote:  

(09-19-2016 09:06 PM)DRE Wrote:  I know I will probably get flamed for this, but leaky gut syndrome (while not disproven), is also not a proven diagnosis. There is really no solid medical literature that proves it exists (someone feel free to correct me). If anyone is having abdominal bloating as a main symptom and has had a negative workup, one possible solution if the FODMAPs diet. Basically foods that tend to have lower gas formation by gut bacteria. Stanford has a good list of foods which are high and low in these compounds.

Just like the "Subluxations" of the Chiropractor, "leaky gut" is the unseen, unproven diagnoses of all manner of New Age specialists.

It may be true that Chiropractors alleging "Subluxations" cause certain diseases has never been proven, I still know that subluxations resulting in vertebral misalignment has a negative impact. I've felt the pain and to quote the infamous wrestling mark from youtube....."it's still real to me damnit".

Post: #24

What's the best anti-candida diet? I don't want to overdo it, there is a lot of speculation, I'm actually an MD, but all I know for a fact is that due to loose bm, i ended up getting irritation that was cured by nystatin

That right there showed me it was candida overgrowth.

I am physically fit, exercise, and have been a picture of health for all of my life. I have no symptoms other than the psyllium requirement to make things firmer.

How far do I have to go with diet to make things more regular, or less hospitable for the yeast, or both?

I'm fairly certain it's a general food problem of the age, but with work and discipline I imagine it can be at least somewhat corrected.

Post: #25

(09-22-2016 10:21 AM)Kid Twist Wrote:  What's the best anti-candida diet? I don't want to overdo it, there is a lot of speculation, I'm actually an MD, but all I know for a fact is that due to loose bm, i ended up getting irritation that was cured by nystatin

That right there showed me it was candida overgrowth.

I am physically fit, exercise, and have been a picture of health for all of my life. I have no symptoms other than the psyllium requirement to make things firmer.

How far do I have to go with diet to make things more regular, or less hospitable for the yeast, or both?

I'm fairly certain it's a general food problem of the age, but with work and discipline I imagine it can be at least somewhat corrected.

First of all cut out white carbohydrates (bread, cookies, pizza, rice, pasta,...) and products with high sugar content, especially alcohol and sodas. That is the base that made candida thriving in your stomach most likely.

Then depending on how bad it is, also cut out fruit, milk products, caffeine, low glycemic load carbs.

Then you need to attack it, by destroying the candida and buy rebuilding the good bacteria. Garlic, ACV, Bicarbonate, anti fungus medicine (fluconazol, Niacin), coconut oil, oregano, ... These are some of the popular options, combine them, because candida does not go away easily. Probiotics, fermented drinks (kombucha), resistant starch can then be used to aid the good bacteria in winning this battle.

Do not underestimate candida, it has wrecked many lives and has been the base for many diseases all over the world. Main cause for it to develop is antibiotics use combined with bad diet. To know when it is gone check your tongue (should not be white). Take into account as well that most likely you´ll have die off symptoms meaning you might get sick or feel bad for a bit before recovering.